In astrology, the first house represents self. It means the appearance, behavior, health, habits are determined in this house. 

And the sixth house debts, disease, pets, enemies and competitions. 

Therefore, having the first house lord in the sixth house means the native’s life will be very much affected by their debts, diseases, and enemies. However, it is not as negative as it looks like. There are many people and professions like money lenders who are involved in debts, doctors who are involved around diseases. And defense personnel who are involved a lot around enemies. It's all about the situation and also the profession. 

So, what happens when the first house lord sits in the sixth house. The results vary from planets to planets and ascendants to ascendants. Let’s go through every planet and their influence on these ascendants one-by-one and learn what is the impact of these:

Sun in sixth house/Sun in 6th house

If the sun is sitting in the sixth house of the Leo ascendants, then the native’s life will be involved in an authoritative position. They may be into some government jobs like a judge or lawyer. There are also chances of them being a government doctor and treating people. All these things solving people’s problems help them boost their morale and increase their confidence.

Moon in sixth house/Moon in 6th house 

 If the moon is sitting on the sixth house of the cancer ascendant, then it's all about care whether in the role of a mother or in a professional field, a nurse. They like to take care of people who are in distress. This caretaker role also involves teachers or spiritual mentors who guide people in their life when they are not very much feeling emotionally strong.

Mars in sixth house/Mars in 6th house 

 Mars rules over two ascendants i.e. Aries Ascendant and Scorpio Ascendant. If the mars are ruling on the sixth house of the Aries ascendant then the person will be very skillful in handling disputes and also be very competitive. This makes them very good lawyers. Defeating their opposition makes them feel confident and they are too good at it too. These natives are very courageous and know how to tackle the ups and downs of life.

And if the mars are ruling on the Scorpio ascendant, then the natives are very good and fighting and by fighting, it means physical fighting. Therefore, they make great defense personals. The natives are also very good at sports and therefore, they will also make very good athletes. 

Mercury in sixth house/Mercury in 6th house 

Mercury also rules over two ascendants i.e. Gemini and Virgo ascendant. If mercury is ruling on the sixth house of the Gemini ascendant, then the native will greatly hold power in communication skills and they will help people as guides and mentors. These people are going through the ups and downs of their life and facing a lot of problems. The natives will help them with spirituality and astrology.

And if the mercury is ruling over the Virgo ascendant, then the native will be surrounded by the conflicts and the disputes. There are high chances that they become lawyers and prosecutors in their life. They also have a very clever mind, which makes them really good at their job.

Venus in sixth house/Venus in 6th house 

Venus also rules over the two ascendants i.e. Taurus and Libra. If the venus is ruling over the Taurus ascendants, then the native will have a very spot for animals. Therefore, they may choose to become veterinarians. However, these people are also very good at calculations and maintaining diplomatic relations. So, they may work in the finance field, like maybe accountants or financial managers.

And if the venus is ruling over the libra ascendants, then also the native is most likely to go for caretaking professions like doctors. Their will for helping others will increase. So, they will choose the devotional path to guide others as well. And as in profession, they will mainly go for social servants.  

Jupiter in sixth house/Jupiter in 6th house 

Jupiter can rule over two ascendants i.e. Sagittarius and Pisces. If Jupiter is ruling over the Sagittarius ascendants, then the native will go for professions related to guidance and counselors. They can also become teachers or health experts to guide people. 

And if Jupiter is ruling over the Pisces ascendants, then the native is most likely to help people as mentors in their disturbed life which are going through its ups and downs. People around the natives find great motivation in them.

Saturn in sixth house/Saturn in 6th house 

Saturn can rule over two ascendants i.e. Capricorn and Aquarius. For both the ascendants, then it is said that they are natural healers. They work for the betterment of poor people. They can even join NGOs for helping them or become lawyers to make sure that these people always receive justice. 

Rahu in sixth house/Rahu in 6th house 

Rahu rules over the Aquarius ascendant. Under this position, the native may be into professions of medicines since Rahu represents medicine and drugs. They will make good pharmacists. They are great healers and help people heal in various ways. They can also become Ayurveda or homeopathy practitioners. 

Ketu in sixth house/Ketu in 6th house 

Ketu rules over the Scorpio ascendant. Under this position, the native feels like lost in their job. They are usually very calm and composed and often very busy with their own work. That is why they always try to avoid any kind of argument with anyone. They have very good health and therefore, usually don’t get sick.